New hydrazone derivatives were synthesized via the nucleophilic addition–elimination
reaction of 2-[(1-methyl-1H-tetrazol-5-yl) thio)] acetohydrazide with aromatic
aldehydes/ketones. The compounds were tested in vitro against various Candida species
and compared with ketoconazole. Genotoxicity of the most effective anticandidal compounds
was evaluated by umuC and Ames assays. All compounds were also investigated for their
cytotoxic effects on NIH3T3 and A549 cell lines. Compound 8 was the most effective …